Stem cells for urinary tract regeneration
نویسندگان
چکیده
Regeneration of the urinary bladder is a complicated task, due to organ dimensions and diseases (cancer, interstitial cystitis) when autologous bladder cells cannot be used. Cancer is the most frequent indication for bladder removal (cystectomy). Stem cells can be used with the guarantee of the sufficient cell number for the in vitro construction of the urinary bladder wall. Tissue engineering techniques hold great promise for regeneration of dysfunctional urinary sphincter. Denervation following surgical procedures or injuries results in weakness of the urethral sphincter and stress urinary incontinence. Injectable therapies and the potential of stem cells for sphincter restoration was presented in this review. The aim of this review was to present possibilities of urinary bladder regeneration with the use of stem cells and tissue engineering techniques.
منابع مشابه
Adipose-Derived Stem Cells — Are They the Optimal Cell Source for Urinary Tract Regeneration?
متن کامل
Adipose Derived Stem Cells for treatment of Lower Genitourinary Dysfunction
Tissue regeneration is the focal point of intensive research efforts that are supported by the increasing number of stem cell sources available. In particular, multipotent mesenchymal stem cells feature many functional properties attractive for regenerative medicine strategies, including their paracrine activity. Adipose-Derived Stromal/Stem Cells (ASCs) have been the focus of extensive work re...
متن کاملStem Cells in Regenerative Endodontics
Background Currently, clinical endodontics includes procedures that are based on the ability of stem cells to accomplish repair (eg, direct pulp capping, apexogenesis, apexification, and even pulpal regeneration). An attempt is made to critically assess the current status in pulp regeneration therapy. Methods: Systematically, 2 distinctly different strategies exist involving stem cells for t...
متن کاملEstablishing a new animal model for muscle regeneration studies
Skeletal muscle injuries are one of the most common problems in the worldwide which impose a substantial financial burden to the health care system. Accordingly, it widely accepted that muscle regeneration is a promising approach that can be used to treat muscle injury patients. However, the underlying mechanisms of muscle regeneration have yet to be elucidated. The muscle structure and muscle...
متن کاملUrodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review
Neurogenic bladder (NGB) secondary to spinal cord injury (SCI) is accompanied with several complications such as urinary tract deterioration, urinary incontinence, and consequently lower quality of life (QoL), significant morbidities, and occasionally death. Current therapeutic methods have some side effects and there is no treatment for the upper urinary tract injuries. Stem cell therapy is a ...
متن کامل